Vitamin D and Dementia Risk

The Journal of Neurology by Codrin Lungu, MD

This large, well-documented, population-based study provides evidence of an association between low levels of vitamin D and an increased risk for dementia, including Alzheimer’s disease.

The study looked at participant’s vitamin D levels 25(OH)D, and separated them into the categories of those who were severely 25(OH)D deficient (<25 nmol/L), deficient (≥25 to <50 nmol/L) and compared the participants with sufficient concentrations(≥50 nmol/L).

It was discovered that the risk of all-cause dementia and Alzheimer disease markedly increased below a threshold of 50 nmol/L.

CONCLUSION Our results confirm that vitamin D deficiency is associated with a substantially increased risk of all-cause dementia and Alzheimer disease. This adds to the ongoing debate about the role of vitamin D in nonskeletal conditions.  Reviewed/posted by Dr. Russell

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